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| First Name: | Iwo | | Last Name: | Bohr | | Title: | Dr. | | Affiliation: | University of Newcastle upon Tyne | | Department: | Institute for Ageing and Health | | Street Address 1: | Westgate Road, | | City: | Newcastle upon Tyne | | Zip/Postal Code: | NE4 6BE | Country/Territory: | United Kingdom | | Phone: | 444 44 07 | | Fax: | +44 191 444 44 02 | | Email Address: |  |
Disclosure:
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Member reports no financial or other potential conflicts of interest. [Last Modified: 25 March 2006]
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View all comments by Iwo Bohr
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Alzheimer Disease, Parkinson Disease, Aging Process
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Neurobiology, Neurotransmission, A-beta PP/A-beta, Neuropathology
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1) Bohr Iwo J (2005) Does cholesterol act as a protector of cholinergic projections in Alzheimer's disease Lipids Health Dis. 2005 Jun 10;4(1):13
http://www.lipidworld.com/content/4/1/13
2) Bohr I. (2004) Hypercholesterolemic diet applied to rat dams protects their offspring against cognitive deficits. Simulated neonatal anoxia model. Physiol Behav 82: 703-711.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15327920&query_hl=4
3) Bohr I.J., Ray M.A., McIntosh J.M., Chalon S., Guilloteau D., McKeith I.G., Perry R.H., Clementi F., Perry E.K., Court J.APiggott . M.A. (2004) Cholinergic nicotinic receptor involvement in movement disorders associated with Lewy body diseases. An autoradiography study using [125I]-conotoxinMII in the striatum and thalamus. Exp Neurol 191/2 pp. 292-300 (February 2005)
http://authors.elsevier.com/sd/article/S001448860400398X
4) Ray M, Bohr I, J. McIntosh M., Ballard C, McKeith I, Chalon S,
Guilloteaud D, Perry R, Perry E., Court J.A., Piggott M. (2004)
Involvement of α6/α3 neuronal nicotinic acetylcholine receptors in neuropsychiatric features of Dementia with Lewy bodies:[125I]-α-conotoxin MII binding in the thalamus and striatum. Neuroscience Letters 372 (2004) 220–225
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15542244&query_hl=6
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- further elucidation of the role played by cholesterol in the brain, especially in relation to cholinergic projections
- elucidating mechanisms leading to the formation of neupathological hallmarks,
- relationship between both hallmarks
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1) Koudinov AR (2005) Cholesterol homeostasis failure as a unifying cause of synaptic degeneration. J Neurol Sci 229-230: 233-240.
2) Lane RM, Farlow MR. (2005) Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease. J Lipid Res. 46: 949-68.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15716586
3)Heverin M, Meaney S, Lutjohann D, Diczfalusy U, Wahren J, Bjorkhem I. (2005) Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain. J Lipid Res. 46: 1047-52. |
biopysical studies aiming at elucididating relationship of plasmalemmal cholesterol with muscarinic and nicotinic receptors using magnetic resonanse and anisotropy of fluorescense. |
"choleterol as a guardian of cholinergic transmission" as presnted in my papers included above. |
There is already enough evidence in favour of it spread out amongst different studies, it would be however valuable to combine these different approaches (amyloid hypothesis, cholinergic theory and cholesterol in relation to both above) in one unifying project. |
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